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DEVELOPMENT AND VALIDATION OF A RAPID AND SIMPLE HPLC-UV METHOD FOR THE ANALYSIS OF SORAFENIB IN THE PRESENCE OF POLYAMIDOAMINE (PAMAM) DENDRIMERS

✍ Scribed by Hashemi, F.; Tamaddon, A. M.; Yousefi, Gh.; Farvadi, F.

Book ID
126963524
Publisher
Taylor and Francis Group
Year
2014
Tongue
English
Weight
317 KB
Volume
37
Category
Article
ISSN
1082-6076

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## Abstract Ras proteins play an important role in the development of cancer. Farnesyl transferase inhibitors (FTIs) block the first obligatory post‐translational step for activation, prenylation, of Ras proteins. To find new potent FTIs, rapid enzyme activity assays are required to reduce FTI deve