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Development and validation of a preclinical model of statin-induced myalgia

โœ Scribed by R. Radhakrishnan; A. Light; R. Hughen


Book ID
118477230
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
33 KB
Volume
12
Category
Article
ISSN
1528-8447

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A preclinical canine model capable of predicting a compound's potential for a human food effect was developed. The beagle dog was chosen as the in vivo model. A validation set of compounds with known propensities for human food effect was studied. Several diets were considered including high-fat dog