Development and validation of a preclini
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Kimberley A. Lentz; Megan Quitko; Daniel G. Morgan; James E. Grace Jr.; Carol Gl
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Article
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2007
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John Wiley and Sons
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English
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A preclinical canine model capable of predicting a compound's potential for a human food effect was developed. The beagle dog was chosen as the in vivo model. A validation set of compounds with known propensities for human food effect was studied. Several diets were considered including high-fat dog