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Development and validation of a novel SPR-based assay principle for bispecific molecules

โœ Scribed by Gassner, C.; Lipsmeier, F.; Metzger, P.; Beck, H.; Schnueriger, A.; Regula, J.T.; Moelleken, J.


Book ID
126536390
Publisher
Elsevier Science
Year
2015
Tongue
English
Weight
869 KB
Volume
102
Category
Article
ISSN
0731-7085

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A method utilizing NMR spectroscopy has been developed to confirm the identity of bacterial polysaccharides used to formulate a polyvalent pneumococcal polysaccharide vaccine. The method is based on 600 MHz proton NMR spectra of individual serotype-specific polysaccharides. A portion of the anomeric