Development and persistence of posttraumatic stress disorder and the 5-HTTLPR polymorphism

✍ Scribed by Geeta A. Thakur; Ridha Joober; Alain Brunet

• Publisher: Springer
• Year: 2009
• Tongue: English
• Weight: 71 KB
• Volume: 22
• Category: Article
• ISSN: 0894-9867
• DOI: 10.1002/jts.20405

✦ Synopsis

Abstract

Association between 5‐HTTLPR polymorphism and development of acute and persistence of chronic posttraumatic stress disorder (PTSD) was prospectively investigated. DNA was extracted from 41 motor‐vehicle accident victims evaluated for development and persistence of PTSD, 1 and 12 months posttrauma. At Time 1, a nonsignificant trend for higher acute PTSD rate in ll homozygotes (82%) was observed compared to those with ss and sl genotypes (50%). At Time 2, higher chronic PTSD rate was found in ll homozygotes (55%) compared to those with ss and sl genotypes (20%), with an odds ratio of 4.8 (95% CI = 1.09–21.22). Contrary to previous findings, these data are suggestive of a protective role for the s allele of 5‐HTTLPR in chronic PTSD.