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Development and maturation of invariant NKT cells in the presence of lysosomal engulfment

✍ Scribed by Tiziana Plati; Ilaria Visigalli; Alessia Capotondo; Mario Buono; Luigi Naldini; Maria Pia Cosma; Alessandra Biffi

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
325 KB
Volume
39
Category
Article
ISSN
0014-2980

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## Abstract NKT cell development takes place in the thymus, beginning when these cells branch away from CD4^+^CD8^+^ mainstream thymocytes upon expression of the VΞ±14JΞ±18 T cell receptor (TCR) and recognition of the CD1d molecule. Although NKT cells express an invariant TCR α chain, the diverse TCR