Development and evaluation of pulsatile drug delivery system using novel polymer
β Scribed by Tekade, Avinash R.; Gattani, Surendra G.
- Book ID
- 126572569
- Publisher
- Informa plc
- Year
- 2009
- Tongue
- English
- Weight
- 936 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1083-7450
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The objective of this work was to develop and evaluate a floating-pulsatile drug delivery system intended for chronopharmacotherapy. Floating-pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. To overcome limitations of va
Selegiline is a selective, irreversible inhibitor of MAO-B, used in the treatment of Parkinson's disease, either alone or as an adjunct to L-DOPA. The sole recommended dosing regimen is 5 mg given in the morning and at noon with breakfast and lunch. A pulsatile oral dosage form was developed to mimi