Development and evaluation of an interface for coupled capillary supercritical fluid chromatography/magnetic sector mass spectrometry. Application to thermally unstable and high molecular mass compounds
✍ Scribed by Mertens, Manuel A. A. ;Janssen, Hans-Gerd M. ;Cramers, Carel A. ;Genuit, Wim J. L. ;van Velzen, Ger J. ;Dirkzwager, Henk ;van Binsbergen, Herman
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 582 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0935-6304
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✦ Synopsis
An interface for coupling supercritical fluid chromatography to a magnetic sector mass spectrometer was developed and evaluated. The interface is based on direct introduction of the mobile phase, carbon dioxide, into the ion-source of the mass spectrometer. The SFC-MS system was optimized with respect to the signal-to-noise ratio. Under optimized conditions, the estimated detection limit for n-pentadecane is approximately 30 ppm. Spectra obtained in the electron-impact ionization mode show a very good similarity with library spectra. The performance of the SFC-MS system was evaluated by the analysis of a number of test mixtures. A sample containing several low molecular mass, thermally unstable compounds, which could neither be analyzed by GC-MS nor by LC-MS, was analyzed. Also for the analysis of high molecular mass compounds, the coupled system showed a good performance.