✦ LIBER ✦
Development and clinical use of the new gastrointestinal prokinetic drug cisapride (R 51 619)
✍ Scribed by André Reyntjens; Marleen Verlinden; Tonny Aerts
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 730 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0272-4391
No coin nor oath required. For personal study only.
✦ Synopsis
Cisapride is a new gastrointestinal prokinetic substance that is devoid of antidopaminergic and direct muscarinic activity. This was evidenced by a lack of effect on prolactin release and gastric secretion. In man, cisapride stimulates lower esophageal, gastric, small intestinal, and colonic motility. Accordingly, cisapride significantly improves esophageal reflux disorders, gastroparesis, and constipation and has been successfully used in the treatment of clinical conditions that result from a deficient motor coordination.