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Development and characterization of mouse monoclonal antibodies reactive with chicken interleukin-2 receptor αlpha chain (CD25)

✍ Scribed by Sung Hyen Lee; Hyun S. Lillehoj; Seung I. Jang; Cynthia Baldwin; Dannielle Tompkins; Bettina Wagner; Mark Parcells; Emilio Del Cacho; Yeong Ho Hong; Wongi Min; Erik P. Lillehoj

Book ID
116966995
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
1019 KB
Volume
144
Category
Article
ISSN
0165-2427

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Blocking of interleukin 2 (IL 2) binding
Blocking of interleukin 2 (IL 2) binding to the IL 2 receptor is not required for the in vivo action of anti-IL 2 receptor monoclonal antibody (mAb). I. The production, characterization and in vivo properties of a new mouse anti-rat IL 2 receptor mAb that reacts with an epitope different to the one that binds to IL 2 and the mAb ART-18
✍ Athanasia Mouzaki; Hans-Dieter Volk; Hisao Osawa; Tibor Diamantstein 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 727 KB

A mouse anti-rat interleukin 2 (IL 2) receptor (IL 2R) monoclonal antibody (mAb), ART-65, has been developed. As shown by fluorescence-activated cell sorter analysis and immunoprecipitation studies, ART-65 recognizes in a species-specific manner the same molecule as does ART-18, a mAb which has been