Real-Time Monitoring of Metabolic Reacti
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Nobuhiro Kobayashi; Izumi Fujimori; Misa Watanabe; Toshihiko Ikeda
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Article
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2000
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Elsevier Science
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English
⚖ 91 KB
Microdialysis combined with tandem mass spectrometry was used to monitor the rapid hydrolysis of CS-866, a new prodrug-type angiotensin II receptor antagonist, in vitro in rat and human plasma as well as in hepatic and intestinal preparations. No chromatographic separation was conducted, and the ion