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Development and Characterization of a Scalable Controlled Precipitation Process to Enhance the Dissolution of Poorly Water-Soluble Drugs

✍ Scribed by True L. Rogers; Ian B. Gillespie; James E. Hitt; Kevin L. Fransen; Cindy A. Crowl; Christopher J. Tucker; Gary B. Kupperblatt; Joe N. Becker; Deb L. Wilson; Clifford Todd; Charles F. Broomall; Jonathan C. Evans; Edmund J. Elder

Book ID
111603753
Publisher
Springer US
Year
2004
Tongue
English
Weight
324 KB
Volume
21
Category
Article
ISSN
0724-8741

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Precipitation of cinnarizine during in vitro lipolysis of a self-microemulsifying drug delivery system (SMEDDS) was characterized to gain a better understanding of the mechanisms behind the precipitation. During in vitro lipolysis of the SMEDDS with or without cinnarizine, samples were taken at seve