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Development and Characterization of a Bispecific Single-Chain Antibody Directed Against T Cells and Ovarian Carcinoma

✍ Scribed by Kriangkum, Jitra; Xu, Biwen; Gervais, Christian; Paquette, Denis; Jacobs, Frederik A.; Martin, Luis; Suresh, Mavanur R.


Book ID
118150756
Publisher
Mary Ann Liebert
Year
2000
Weight
393 KB
Volume
19
Category
Article
ISSN
0272-457X

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A recent study reported on an anti-CD19/anti-CD3 single-chain bispecific antibody (bscCD19xCD3) exhibiting high activity against human B lymphoma cell lines (LΓΆffler et al., Blood 2000;95:2098-103). In the present study, we have explored in detail the in vitro efficacy, T-cell donor variability, bin