Development and characterization of a biodegradable polyphosphate

✍ Scribed by Renier, Michael L. ;Kohn, David H.

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 333 KB
• Volume: 34
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(199701)34:1<95::aid-jbm13>3.0.co;2-o

✦ Synopsis

A biodegradable polyphosphate polymer (M n ϭ 18,000, M w / in PBS than in bovine serum. In vitro release of OP-1 was M n ϭ 3.2) matrix system was developed as a potential deliv-also faster in PBS than in serum. Release kinetics of OP-1 ery vehicle for growth factors. As a model system, release in PBS and serum were represented by second-order polyof recombinant human osteogenic protein-1 (OP-1) from this nomials. The OP-1 release from this physically dispersed polymer was evaluated. The polyphosphate was synthesized polymeric matrix may be described by several possible using a triethylamine catalyst in an argon environment, and mechanisms: diffusion, bulk polymer degradation, ion comcharacterized using elemental analysis, gel permeation chro-plexation, and interactions among the protein (OP-1), polymatography (GPC), and Fourier transform infrared spectros-mer, proteins, and enzymes in the media. This polyphosphate copy (FTIR). Degradation kinetics of the polyphosphate poly-may be an effective carrier for morphogens, growth factors, mer in phosphate-buffered saline (PBS) were represented or other classes of bioactive molecules. ᭧ 1997 John

Wiley & Sons, Inc.

by a second-order polynomial while degradation in bovine serum was linear with time. The polymer degraded faster *To whom correspondence should be addressed.