Development and characterisation of a collagen nano-hydroxyapatite composite scaffold for bone tissue engineering
✍ Scribed by Gráinne M. Cunniffe; Glenn R. Dickson; Sonia Partap; Kenneth T. Stanton; Fergal J. O’Brien
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 449 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0957-4530
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## Abstract The objective of this study was to develop a biomimetic, highly porous collagen‐hydroxyapatite (HA) composite scaffold for bone tissue engineering (TE), combining the biological performance and the high porosity of a collagen scaffold with the high mechanical stiffness of a HA scaffold.
## Abstract Tissue‐engineering scaffold‐based strategies have suffered from limited cell depth viability when cultured __in vitro__, with viable cells existing within the outer periphery of the fluid–scaffold interface. This is primarily believed to be due to the lack of nutrient delivery into and