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Deuterium isotope effects as a conformational probe in cyclic and acyclic ketones

โœ Scribed by Stefan Berger; Bernd W. K. Diehl

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
516 KB
Volume
26
Category
Article
ISSN
0749-1581

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โœฆ Synopsis

Cyclic ketones from cyclobutanone to cyclohexadecanone were labelled with deuterium in the a-position. The deuterium isotope effect on the ''C NMR spectra was measured and in some cases was indicative of perturbation of conformational equilibrium. Similar effects were observed with acyclic ketones. The results were confirmed by temperature-dependent measurements and molecular mechanics calculations.

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