A solvent deuterium isotope effect on the catalytic affinity (K(m)) and rate constant (k(cat)) of tyrosinase in its action on 4-tert-butylcatechol (TBC) was observed. Both parameters decreased as the molar fraction of deuterated water in the medium increased, while the k(cat)/K(m) ratio remained con
✦ LIBER ✦
Deuterium isotope effect on the suicide inactivation of tyrosinase in its action on o- diphenols
✍ Scribed by Muñoz-Muñoz, Jose Luis; del Mar García-Molina, María; Garcia-Molina, Francisco; Garcia-Ruiz, Pedro Antonio; Garcia-Sevilla, Francisco; Rodriguez-Lopez, Jose N.; Garcia-Canovas, Francisco
- Book ID
- 120981370
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 455 KB
- Volume
- 65
- Category
- Article
- ISSN
- 1521-6543
- DOI
- 10.1002/iub.1191
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## Abstract In the rodent liver, hepatocarcinogens inhibit the glucocorticoid induction of several liver‐specific genes, including tyrosine aminotransferase (__TAT__). A distinct positive correlation exists in mice between the extent of inhibition of TAT induction after acute administration of __o_