Deuterated anabolic drugs. Part 2 synthesis of (R,S)-3, 4-bis(4-hydroxyphenyl)-[2,2,5,5-d 4]hexane (HEX-d4) and (E,E)-3,4-bis(4-hydroxyphenyl)-[2,5-d2]hexa-2,4-diene (DE-d2)

✍ Scribed by Gijsbert Zomer; Henk J. G. M. Derks; Hans Wynberg

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: French
• Weight: 223 KB
• Volume: 21
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580210208

✦ Synopsis

D e u t e r a t e d a n a b o l i c d r u g s . P a r t 2 S y n t h e s i s o f ( R , S ) -3 , 4 -b i s ( 4-hydroxyphenyl)-[2,2,5,5-d l h e x a n e ( HEX-d a n d (E,E)-3,4-bis(4-hydroxyphenyl)-[2,5-d l h e x a -2 , 4 -d i e n e (DE-d ) 4 4 2 2 G i j s b e r t Zomer, Henk J.C.M. D e r k s a n d H a n s W y n b e r g ( * ) N a t i o n a l I n s t i t u t e o f P u b l i c H e a l t h L a b o r a t o r y o f C l i n i c a l C h e m i s t r y a n d H a e m a t o l o g y , P.O. b o x 1 , 3 7 2 0 BA B i l t h o v e n . T h e N e t h e r l a n d s ( * I D e p a r t m e n t o f O r g a n i c C h e m i s t r y U n i v e r s i t y o f G r o n i n g e n , N i j e n b o r g h 1 6 , 9 7 4 7 AC C r o n i n g e n , T h e N e t h e r l a n d s Summary Hex e s t r o l -d w a s s y n t h e s i z e d f r o m 1 -h y d r o x y -l pm e t h o x y p h e n y l -[ 2 , 2 -d ] p r o p a n e