Determining the absolute configuration of hindered secondary alcohols - a modified horeau's method

✍ Scribed by David E. Barnekow; John H. Cardellina II

• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 219 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)80466-4

✦ Synopsis

Susanary -The kinetic resolution of racemic 2-phenylbutyryl chloride by hindered chiral secondary alcohols has been shown to be a viable approach to the determination of the absolute configuration of secondary alcohols through a study of ten chiral alcohols.

For nearly three decades, Horeau's method1 for determining the stereochem-