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Determination of zopiclone enantiomers in plasma by liquid chromatography using a chiral cellulose carbamate column

✍ Scribed by Christine Fernandez; Bruno Baune; François Gimenez; Alain Thuillier; Robert Farinotti

Publisher
Elsevier Science
Year
1991
Weight
492 KB
Volume
572
Category
Article
ISSN
0378-4347

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Determination of darusentan enantiomers
Determination of darusentan enantiomers in rat plasma by enantioselective liquid chromatography with tandem mass spectrometry using cellulose-based chiral stationary phase
✍ Jianmin Gu; Xiaowei Shi; Yumin Du; Wei Wang; Xiufang Du; Lantong Zhang 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB

## Abstract A sensitive, specific and rapid liquid chromatography–mass spectrometry (LC‐MS/MS) method has been developed and validated for enantioselective determination of darusentan enantiomers, orally active potent endothelin‐A receptor antagonist, in rat plasma. The plasma samples were pretreat