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Determination of zinc stable isotopes in biological materials using isotope dilution inductively coupled plasma mass spectrometry

✍ Scribed by Kristine Y. Patterson; Claude Veillon; Phylis B. Moser-Veillon; Gordon F. Wallace

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
734 KB
Volume
258
Category
Article
ISSN
0003-2670

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✦ Synopsis

A method 1s described for usmg Isotope dllutlon to determme both the amount of natural zmc and enriched Isotopes of zmc m blologlcal samples Isotope ddutlon mductwely coupled plasma mass spectrometly offers a way to quantify not only the natural zmc found m a sample but also the ennched isotope tracers of zmc Accurate values for the enriched Isotopes and natural zmc are obtamed by adlustmg the mass count rate data for measurable instrumental biases Analytical mterferences from the matrur are avoided by extractmg the zmc from the sample matrm using dlethylammomum dlethyldlthlocarbamate The extractlon techmque separates the zmc from elements which form mterfermg molecular ions at the same nominal masses as the zmc Isotopes Accuracy of the method IS verified usmg standard reference matenals The detection hrmt 1s 0 06 pg Zn per sample Preclslon of the abundance ratios range from 0 3-O 8% R S D for natural zmc. concentrations of about 200400 pg g-' The accuracy and precision of the measurements make It possible to follow ennched Isotopic tracers of zmc m blolomcal samples III metabolic tracer studies Keyword Mass spectrometry, Blologlcal matenals, Isotope ddutlon, Zmc

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