Determination of warfarin in drinking water by high-performance liquid chromatography after solid-phase extraction

✍ Scribed by Johan Dalbacke; Irene Dahlquist; Christiane Persson

• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 398 KB
• Volume: 507
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(01)84215-1

✦ Synopsis

A method for the determination of 0.1 pg/l of warfarin in drinking water involving concentration by solid-phase extraction is described. A lOOO-ml volume of drinking water is aspirated through a solid-phase extraction column and warfarin is eluted to 1.0 ml. The eluate is analysed by reversed-phase high-performance liquid chromatography with UV detection. The detection limit is 0.02 pg/l. Recoveries of greater than 90% were obtained when tap water was spiked with warfarin.