HES-1 is a vertebrate homologue of the Drosophila basic helix-loop-helix (bHLH) protein Hairy, a transcriptional repressor that negatively regulates neuronal differentiation. HES-1 expression in neuronal precursors precedes and represses the expression of the neuronal commitment gene MASH-1, a bHLH
β¦ LIBER β¦
Determination of vertebrate retinal progenitor cell fate by the Notch pathway and basic helix-loop-helix transcription factors
β Scribed by M. Perron; W. A. Harris
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 922 KB
- Volume
- 57
- Category
- Article
- ISSN
- 1420-682X
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## Abstract Elucidation of the intricate transcriptional pathways leading to neural differentiation and the establishment of neuronal identity is critical to the understanding and design of therapeutic approaches. Among the important players, the basic helixβloopβhelix (bHLH) transcription factors