Near infrared spectroscopy (NIRS) was utilized to determine the water content during the drying of a drug substance with Karl Fisher titration as the reference measurement. NIRS calibration models were built with Partial Least Squares (PLS) regression based on spectral region of 1822-1948 nm for sam
Determination of trace amounts of water in glycerides by near-infrared spectroscopy
β Scribed by R. J. Warren; J. E. Zarembo; C. W. Chong; M. J. Robinson
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 200 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
β¦ Synopsis
A rapid accurate method for determining trace amounts of water in glycerides is presented. The method is based on the measurement of the combination band for water which occurs at 1.896 , L I in chloroform solution. In addition to the advantage of making it possible to work at low levels, the method is specific for water and free of interferences due to other OH groups. Several commercial samples of glyceryl mono-and distearates were analyzed by this method, and showed water contents of 0.4 to 1.2%.
Keyphrases 0 Glycerides-water determination Water determination-trace amounts Near IR spectrophotometry-analysis
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