Determination of Tissue Partition Coefficients for Volatile Tissue-Reactive Chemicals: Acrylonitrile and Its Metabolite 2-Cyanoethylene Oxide

An in vitro method for determination of

An in vitro method for determination of tissue partition coefficients of non-volatile chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and estradiol

✍ John E. Murphy; Derek B. Janszen; Michael L. Gargas 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 688 KB

The development of an in vitro vial equilibration technique for determining tissue and liquid partition coefficients for non-volatile chemicals is described. Radiolabeled chemical dissolved in propylene carbonate is equilibrated with tissues or liquid at 37°C in a vial system. The solvent must be es