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Determination of the ϕ angle in a peptide backbone by NMR spectroscopy with a combination of homonuclear and heteronuclear coupling constants

✍ Scribed by Peter Schmieder; Horst Kessler

Publisher: Wiley (John Wiley & Sons)
Year: 1992
Tongue: English
Weight: 393 KB
Volume: 32
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360320421

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✦ Synopsis

Abstract

The ϕ angle in a cyclic peptide is determined by the combined use of homonuclear and heteronuclear coupling constants. Two of the four coupling constants that define the ϕ angle in a peptide are determined exactly, two qualitatively. Via Karplus‐type equations, they are transformed into dihedral angles and a good agreement is found, allowing for a determination of the ϕ angle with a certain range of degrees.

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