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Determination of the relative contributions of the diselenide and selenol forms of ebselen in the mechanism of its glutathione peroxidase-like activity

โœ Scribed by Ralf Morgenstern; Ian A. Cotgreave; Lars Engman


Book ID
113137575
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
373 KB
Volume
84
Category
Article
ISSN
0009-2797

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Evidence for a common selenolate interme
โœ Lars Engman; Claes Andersson; Ralf Morgenstern; Ian A. Cotgreave; Carl-Magnus An ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 638 KB

The glutathione peroxidase-like catalysis of a-(phenylselenenyl) ketones was investigated. Degradation studies demonstrated the rapid cleavage of the aliphatic carbon-selenium bond of a-(phenylselenenyl) ketones by glutathione at pH 6.9 in a methanolic phosphate buffer under argon. On treatment with