Determination of the pharmacokinetics of 2-amino-7-phosphonoheptanoate in rat plasma and cerebrospinal fluid
β Scribed by Compton, Robert P.; Hood, William F.; Monahan, Joseph B.
- Book ID
- 122622859
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 336 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0304-3940
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## Abstract The aim of this study was to investigate the pharmacokinetic behavior of huperzine A (Hup A) in plasma and cerebrospinal fluid (CSF) after intranasal administration (0.5βmg/kg) in male SpragueβDawley rats. A pharmacokinetic study of intravenous Hup A (0.5βmg/kg) was also performed. The
There is now considerable evidence that the N-methyl-D-aspartic acid receptor is important in the genesis of seizures. One of the selective antagonist of the NMDA receptor is 2-amino-7-phosphonoheptanoic acid (APH). In this study we evaluated the effects of intracerebroventricular (i.c.v.) administr