Determination of the molecular conformation of β-D-O2,2′-cyclouridine in aqueous solution by proton magnetic resonance spectroscopy

✍ Scribed by Bradford P. Cross; Thomas Schleich

• Publisher: Wiley (John Wiley & Sons)
• Year: 1973
• Tongue: English
• Weight: 470 KB
• Volume: 12
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/bip.1973.360121016

✦ Synopsis

Abstract

The solution conformation of β‐D‐O^2^,2′‐cyclouridine has been determined at 27 and 88°C in D~2~O by proton magnetic resonance spectroscopy. The conformation is described in terms of a fixed syn‐like sugar‐base torsional angle, a type S furanose ring conformation (similar to 2′‐endo), and a temperature‐dependent exocyclic C(4)′–C(5′) rotamer population containing approximately 50% of the gauche‐gauche form at 27°C. β‐D‐O^2^,2′‐Cyclouridine 5′‐phosphate likewise possesses a type S furanose ring conformation.