Determination of the lysosomal role in tumor accumulation of 67Ga by dual-tracer studies

✍ Scribed by Atsushi Ando; Itsuko Ando; Tatsunosuke Hiraki; Norihisa Yamada; Kinichi Hisada

• Publisher: Elsevier Science
• Year: 1989
• Weight: 227 KB
• Volume: 40
• Category: Article
• ISSN: 0883-2889
• DOI: 10.1016/0883-2889(89)90138-x

✦ Synopsis

The lysosomal role in tumor accumulation of 67Ga was determined by dual-tracer (67Ga and 46Sc) studies. It became clear that 67Ga essentially did not accumulate in the tumor lysosome, and that the lysosome did not play a major role in tumor accumulation of 67Ga. In addition, it was revealed that tumor lysosome was hardly disrupted at all in some phases of fractionation procedures.