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Determination of the hydrophobicity parameter RMw by reversed-phase thin-layer chromatography

✍ Scribed by Karl Dross; Christoph Sonntag; Raimund Mannhold

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
975 KB
Volume
673
Category
Article
ISSN
1873-3778

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The hydrophobicity and specific hydrophilic surface area of 29 antibiotics were determined by reversed-phase thin-layer chromatography using impregnated silica and alumina supports and methanol :water mixtures as eluents. It was found that the supports retain their original retention characteristics