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Determination of the enantiomers of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in plasma and urine using enantioselective gas chromatography with mass spectrometric detection

✍ Scribed by Camille P. Granville; Bärbel Gehrcke; Wilfried A. König; Irving W. Wainer


Publisher
Elsevier Science
Year
1993
Weight
714 KB
Volume
622
Category
Article
ISSN
0378-4347

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A sensitive method for the simulataneous determination of bufuralol and its pharmacologically active metabolites in huamn plasma is described. The O-timethylsilyl,N-trifluoroacetyl derivatives are assayed by mass fragmentography. Sensitivity is 1 ng 76(-1) plasma for bufaralol and about 250 pg ml(-1