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Determination of the Active Metabolite of Prulifloxacin in Human Plasma by HPLC with Fluorescence Detection

✍ Scribed by Jun Wen; Zhenyu Zhu; Zhanying Hong; Yiwen Wu; Yan Fei; Mei Lin; Guorong Fan; Yutian Wu


Book ID
111790776
Publisher
Springer
Year
2007
Tongue
English
Weight
238 KB
Volume
66
Category
Article
ISSN
0009-5893

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A simple and sensitive HPLC method has been developed for the simultaneous determination of enrofloxacin (ENR) and ciprofloxacin (CIP) in plasma. Plasma sample preparation was carried out by adding phosphate buffer (pH 7.4, 0.1 M), followed by extraction with trichloromethane. ENR, CIP and the inter