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Determination of Testosterone Metabolites in Rat Hepatocytes with and without Cryopreservation by On-Line SPE Column-Switching LC and MS Detection

โœ Scribed by Gerhard Friedrich; Thorsten Rose; Alexander Wawkuschewski; Sabine Kafert-Kasting; Britta Laube; Lubomir Arseniev; Klaus Rissler


Book ID
111790990
Publisher
Springer
Year
2007
Tongue
English
Weight
410 KB
Volume
67
Category
Article
ISSN
0009-5893

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A highly sensitive and selective liquid chromatography/ionspray tandem mass spectrometry (LC/MS/MS) method was developed and validated for the determination of Pranlukast and its oxidative metabolites (SB 240103, SB 241484 and SB 218663) in human plasma in order to support pharmacokinetic studies. T