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Determination of telmisartan in rat tissues by in-tube solid-phase microextraction coupled to high performance liquid chromatography

✍ Scribed by Jing Nie; Qun Zhao; Jingfang Huang; Bingren Xiang; Yu-Qi Feng

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
417 KB
Volume
29
Category
Article
ISSN
1615-9306

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✦ Synopsis

Determination of telmisartan in rat tissues by in-tube solid-phase microextraction coupled to high performance liquid chromatography A poly(methacrylic acid-ethylene glycol dimethacrylate, MAA-EGDMA) monolithic capillary was used for the direct and on-line extraction of telmisartan from Sprague-Dawley rat tissue (heart, kidney, and liver) homogenates. Under optimized conditions, the tissue homogenates were simply diluted with a mixture of phosphate buffer (pH 2)/ACN (90 : 8 v/v), and then injected for extraction only after centrifugation and filtration. Coupled to HPLC with fluorescence detection, the method was linear over the range of 1.25 -1500 ng/g for telmisartan in heart and kidney, 12.5 -15 000 ng/g in liver with correlation coefficients over 0.9992. The detection limits were found to be in the range from 0.24 to 1.8 ng/g. RSDs for intra-and inter-day ranged from 1.2 to 8.1%. The determination of telmisartan in treated rat tissues was achieved by using the proposed method.

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