Determination of selenium in drugs by oxygen flask combustion and ion chromatography

✍ Scribed by Mitsunori Murayama; Masao Suzuki; Shoji Takitani

• Publisher: Elsevier Science
• Year: 1989
• Tongue: English
• Weight: 406 KB
• Volume: 463
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(01)84462-9

✦ Synopsis

A method is described for the determination of trace selenium (impurities in medicinal organic compounds) by ion chromatography (IC) after oxygen flask combustion. All selenium compounds formed by oxygen flask combustion are converted to selenate ion by heating with nitric acid and potassium permanganate. The selenate ion is then determined by IC, using a simple recycle system to eliminate interfering ions. The detection limit of selenium is 0.4 nmol in 50 mg of-sample. The recoveries of selenium added to seven drugs are cu. 95-103% with relative standard deviations of l-6%.