Determination of pyrrolizidine alkaloids in commercial comfrey products (Symphytum sp.)

Characteristic ion clusters as determina

Characteristic ion clusters as determinants for the identification of pyrrolizidine alkaloid N-oxides in pyrrolizidine alkaloid–containing natural products using HPLC–MS analysis

✍ Jianqing Ruan; Na Li; Qingsu Xia; Peter P. Fu; Shuying Peng; Yang Ye; Ge Lin 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 507 KB

Pyrrolizidine alkaloid (PA)-containing plants are widely distributed in the world. PAs are hepatotoxic, affecting livestock and humans. PA N-oxides are often present together with PAs in plants and also exhibit hepatotoxicity but with less potency. HPLC-MS is generally used to analyze PA-containing