Determination of protein structures from nuclear magnetic resonance data using a restrained molecular dynamics approach: The lac repressor DNA binding domain

Combined procedure of distance geometry

Combined procedure of distance geometry and restrained molecular dynamics techniques for protein structure determination from nuclear magnetic resonance data: Application to the DNA binding domain of lac repressor from Escherichia coli

✍ J. de Vlieg; R. M. Scheek; W. F. van Gunsteren; H. J. C. Berendsen; R. Kaptein; 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 981 KB

The technique of two-dimensional nuclear magnetic resonance (2D-NMR) has recently assumed an active role in obtaining information on structures of polypeptides, small proteins, sugars, and DNA fragments in solution. In order to generate spatial structures from the atom-atom distance information obta