Although interactions of proteins with glycosaminoglycans (GAGs), such as heparin and heparan sulphate, are of great biological importance, structural requirements for protein-GAG binding have not been well-characterised. Ionic interactions are important in promoting protein-GAG binding. Polyelectro
Determination of protein binding parameters in systems involving interaction between sites
β Scribed by Theodore D. Sokoloski; Betty-Ann Hoener
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 348 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Plasminogen activator inhibitor type-1 (PAI-1) is bound to vitronectin (VN) in plasma and in the extracellular matrix. We previously employed a domainswapping approach to show that the high-affinity binding site for PAI-1 in VN is contained within residues 12-30 in the amino-terminal somatomedin B (
## Abstract Insulinβlike growth factor binding protein (IGFBP)β6 has been reported to inhibit differentiation of myoblasts and osteoblasts. In the current study, we explored the mechanisms underlying IGFBPβ6 effects on osteoblast differentiation. During MC3T3βE1 osteoblast differentiation, we found
An interpretation based on more precise linear free energy relationships is proposed for the determination of the acid-base interaction of a solid surface, in the context of inverse gas chromatography at infinite dilution. This work leads to the evaluation of acid-base interaction parameter, I aΨb ,
## Abstract In several previous studies, we performed sensitivity analysis to gauge the relative importance of different atomic partial charges in determining proteinβligand binding. In this work, we gain further insights by decomposing these results into three contributions: desolvation, intramole
In the current study, we report that cytochalasin-induced disruption of microfilaments stabilizes lymphokine mRNAs in activated human peripheral blood lymphocytes. Parallel with this, a dose-and time-dependent increase in AU-rich sequence binding protein (AUPB) activities is apparent in the nonionic