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Determination of population pharmacokinetic parameters for amikacin in neonates using mixed-effect models

✍ Scribed by J. H. Botha; M. J. du Preez; R. Miller; M. Adhikari


Publisher
Springer
Year
1998
Tongue
English
Weight
307 KB
Volume
53
Category
Article
ISSN
0031-6970

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## Abstract Nonlinear mixed effects models are now widely used in biometrical studies, especially in pharmacokinetic research or for the analysis of growth traits for agricultural and laboratory species. Most of these studies, however, are often based on ML estimation procedures, which are known to