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Determination of plasma and brain concentrations of SCH 39166 and their correlation to conditioned avoidance behavior in rats

✍ Scribed by Clark E. Tedford; Vicki L. Coffin; Vilma Ruperto; Mary Cohen; Robert D. McQuade; Richard Johnson; Hong-Ki Kim; Chin-Chung Lin


Book ID
105510870
Publisher
Springer
Year
1993
Tongue
English
Weight
802 KB
Volume
113
Category
Article
ISSN
0033-3158

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A previously reported method of measuring tricyclic antidepressant concentrations in brain tissue and plasma was used to measure amitriptyline (AMI) in rats following drug administration using different routes, doses, and time intervals. In rats given AMI intraperitoneally (IP), brain concentrations