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Determination of phenylbutyric acid and its metabolite phenylacetic acid in different tissues of mouse by liquid chromatography with tandem mass spectrometry and its application in drug tissue distribution

✍ Scribed by Anu Marahatta; Bidur Bhandary; Mi-Rin Lee; Do-Sung Kim; Yong Chul Lee; So-Ri Kim; Hyung-Ryong Kim; Han-Jung Chae

Book ID
119289227
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
605 KB
Volume
903
Category
Article
ISSN
1873-376X

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A sensitive and speciÐc method was developed and validated to quantitate lovastatin and its hydroxy acid in mouse and rat plasma. This method employs a solid-phase extraction procedure to isolate lovastatin and its hydroxy acid metabolite from the biological matrices (0.1 ml of mouse or rat plasma).