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Determination of Paracetamol in the Presence of Caffeine and Acetylsalicylic Acid in Analgesic Formulations by the Linear Absorbances Method and the Derivative Spectroscopy Technique

✍ Scribed by M.C. Pascualmarti; A. Cerdanvidal; M. Llobatestelles

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 414 KB
Volume: 49
Category: Article
ISSN: 0026-265X
DOI: 10.1006/mchj.1994.1006

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✦ Synopsis

The simultaneous use of the linear absorbances method and the derivative spectroscopy technique allows paracetamol to be spectrometrically determined in the presence of two interfering drugs that are generally associated with paracetamol in analgesic formulations. The proposed procedure does not need standard solutions of the interfering drugs; only a test solution of acetylsalicylic acid (ASA) is needed. The ASA contents can be also determined with good accuracy by routine and control analysis. The procedure is applied to two commercial pharmaceutical samples. (1994 Academic Press, inc.

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