Determination of opiates and other basic drugs by high-performance liquid chromatography with electrochemical detection

✍ Scribed by J.G. Besner; C. Band; J.J. Rondeau; L. Yamlahi; G. Caillé; F. Varin; J. Stewart

• Publisher: Elsevier Science
• Year: 1989
• Tongue: English
• Weight: 416 KB
• Volume: 7
• Category: Article
• ISSN: 0731-7085
• DOI: 10.1016/0731-7085(89)80198-0

✦ Synopsis

A procedure is described for the extraction and determination of morphine (M), hydromorphone (HM), codeine (C) and metoclopramide (MCP) present in human plasma. The drugs are separated by reversed-phase liquid chromatography and detected amperometrically at a glassy carbon electrode. The method provides high sensitivity and selectivity and has been used successfully in bioavailability studies.