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Determination of nanogram amounts of primary aromatic amines and nitro compounds in blood and plasma

✍ Scribed by P. Haefelfinger

Publisher: Elsevier Science
Year: 1975
Tongue: English
Weight: 511 KB
Volume: 111
Category: Article
ISSN: 1873-3778
DOI: 10.1016/s0021-9673(00)99281-1

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✦ Synopsis

A rapid and highly sensitive method, based on the direct fluorimctric scanning of thin-layer chromatograms, is described for the quantitative determination of flunitrazepam and its main metabolitcs in human blood or plasma. This method is generally applicable to aromatic nitro compounds that are reducible with tin(Il) chloride. In particular, it is possible to determine primary amincs in nanogram amounts. Fluorescamine is used as a reagent to produce fluorescent derivatives. The method is suitable for pharmacokinctic studies of flunitrazepam and its main metabolites in human blood and plasma. PRlNCIPLE OF THE METHOD Flunitrazcpam and its main mctabolitcs arc extracted from human plasma or __ _.._ ._ l Active principle of the hypnotic prcpslration Rohypnol (Rochc trade marl+

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