Determination of molar mass and radius of gyration by size exclusion chromatography with on-line viscometer and multi-angle laser light scattering. High temperature characterization of polystyrene

Characterization of high-molecular-weigh

Characterization of high-molecular-weight nonnative aggregates and aggregation kinetics by size exclusion chromatography with inline multi-angle laser light scattering

✍ Yi Li; William F. Weiss IV; Christopher J. Roberts 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 344 KB

Size exclusion chromatography with an inline multi-angle light scattering detector (SEC-MALS) was assessed as a means to characterize and monitor the formation of soluble, high-molecular-weight (HMW) protein aggregates so as to better quantify and model nonnative aggregation kinetics. Assay configur