Determination of lorazepam in plasma by electron capture GLC

✍ Scribed by G. Groot; R. A. A. Maes; H. H. J. Lemmens

• Book ID: 104708610
• Publisher: Springer-Verlag
• Year: 1976
• Tongue: English
• Weight: 262 KB
• Volume: 35
• Category: Article
• ISSN: 0340-5761
• DOI: 10.1007/bf00293571

✦ Synopsis

A method is described for the determination of lorazepam plasma levels involving extraction from the sample and analysis of the intact lorazepam by electron capture gas-liquid chromatography. Using mass spectrometry it is demonstrated, that lorazepam shows a thermal rearrangement under gas chromatographic conditions. The limit of detection is 0.01 mg/l and the assay shows a linearity from 0.01-0.80 mg lorazepam per liter of plasma.