A method is described for the evaluation of drug concentrations in plasma and brain from treated rats. The analyte is recovered from plasma or brain homogenate by liquid-liquid extraction and subsequently analyzed by liquid chromatography/tandem mass spectrometry (LC/MS/MS). A simple experimental pr
β¦ LIBER β¦
Determination of lopinavir cerebral spinal fluid and plasma ultrafiltrate concentrations by liquid chromatography coupled to tandem mass spectrometry
β Scribed by Robin DiFrancesco; Robert DiCenzo; Glorimar Vicente; Julie Donnelly; Troy M. Martin; Luis A. Colon; Giovanni Schifito; Gene D. Morse
- Book ID
- 108189419
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 328 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0731-7085
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## Abstract A simple, sensitive and rapid highβperformance liquid chromatography/electrospray ionization tandem mass spectrometry method was developed and validated for the assay of granisetron in human plasma. Following liquidβliquid extraction, the analytes were separated using an isocratic mobil