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Determination of Kinetic Rate Constants for the Binding of Inhibitors to HIV-1 Protease and for the Association and Dissociation of Active Homodimer

✍ Scribed by Pargellis, Christopher A.; Morelock, Maurice M.; Graham, Edward T.; Kinkade, Peter; Pav, Susan; Lubbe, Klaus; Lamarre, Daniel; Anderson, Paul C.


Book ID
126924915
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
980 KB
Volume
33
Category
Article
ISSN
0006-2960

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## Abstract The kinetic constants for the interactions between HIV‐1 protease and a selection of inhibitors were determined at different pH‐values using a biosensor based interaction assay. Since this technique does not involve a substrate, it was possible to determine the pH‐dependencies of the as