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Determination of hydration equilibrium constants and pKa values of 4-piperidones in buffered water solutions

✍ Scribed by J. J. Van Luppen; J. A. Lepoivre; R. A. Dommisse; F. C. Alderweireldt

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 421 KB
Volume: 12
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1270120704

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✦ Synopsis

Abstract

^1^H and ^13^C chemical shift parameters are given for 4‐piperidones and their derivatives in buffered aqueous solution. The ^13^C shift increments of methyl substituents on the nitrogen atom are discussed. The pH‐shift dependence is studied in detail and p__K__~a~ values are given for ketone forms and hydration products. The hydration equilibria are measured as a function of pH and temperature.

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