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Determination of homovanillic acid in urine by stable isotope dilution and electrospray tandem mass spectrometry

✍ Scribed by Mark J Magera; Amy L Stoor; Janice K Helgeson; Dietrich Matern; Piero Rinaldo


Book ID
117074180
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
163 KB
Volume
306
Category
Article
ISSN
0009-8981

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## Abstract __N__‐acetylaspartic acid (NAA) is a specific urinary marker for Canavan disease, an autosomal recessive leukodystrophy. We developed a ‘dilute and shoot’ stable isotope dilution liquid chromatography tandem mass spectrometry (LC‐MS/MS) method for determination of NAA in urine. Deuterat